Working memory and neurogenesis at the Bay Area Neuroscience Gathering

By Lumos Labs Science Associate Paul Li, MS Neuroscience.

Last Friday afternoon, UCSF held their annual Bay Area Neuroscience Gathering (BANG) where local grad students and neuroscientists showcased their research posters to the Bay Area neuroscience community. Universities included UCSF, UC Davis, UC Berkeley, San Francisco State and Stanford. Lumos Labs presented an investigation into web-based experimentation and cognitive training.

Though not many posters were directly related to brain health, I wanted to report the ones that were of relevance and of possible interest to you:

Wesley Clapp, PhD at UCSF found subjects consolidate information differently in their working memory when they know they will face distractors than without any distractors present. They looked at two electroencephalography (EEG) signals that are associated particularly with memory, attention, and perception: the P100 and the N170 (these are electrical signals from the brain that occur at 100 and 170 milliseconds after the event has happened). Clapp and colleagues found that these latencies are modulated differently depending on if the information presented to the subject is relevant or not. He also showed that the amount subjects pay attention to irrelevant information directly correlates with their impairment in working memory performance. To learn more, see Clapp’s research poster.

Leslie Meltzer, a Ph.D student working with Karl Deisseroth at Stanford is studying the effects of antidepressants in rodent models of depression. Meltzer and colleagues found that the therapeutic effects of antidepressants required the growth of new neurons in the hippocampus, a brain region important for memory formation. This suggests that antidepressants might improve mood by increasing the production of new neurons. During Alzheimer’s disease, neurons in the hippocampus begin to die. Could antidepressants be helpful for fighting off dementia? It’s possible, but there are too many unknowns to have a clear picture. Bear in mind that a combination of mental and physical exercises, the types of food we eat, and social activities we do all matter in shaping the condition of our brain.