Targeted Cognitive Exercises Improve Mental Abilities

Training with cognitive exercises can improve targeted mental functions, conclude the authors of a review article published recently in the journal Alzheimer’s and Dementia.  The authors (Kathryn Papp and Stephen Walsh from the University of Connecticut and Peter Snyder from Brown University) reviewed ten randomized controlled trials involving cognitive training interventions in healthy adults published since 1992.  They find that specific abilities such as memory, reasoning, and speed of processing can be improved through targeted training programs.  This is an important conclusion, and it is consistent with the growing evidence in support of the effectiveness of cognitive training.

The authors point out that the benefits of cognitive training tend to be specific to the trained domain.  So, if you want improved memory — train on games designed to improve memory.  If you want improved attention — train with attention games, and so on.  The relationship to physical exercise is apparent.  If you want big biceps — do curls.  If you want ripped abs — do sit ups.  Lumosity was designed with these principles in mind.  This is why the site contains over 30 games targeting cognitive functions spanning speed of processing, memory, attention, flexibility, and problem solving — a complete gym for the brain.

It is also clear from this review that there is still much to learn.  Few of the studies have follow-up testing longer than a few months, and many of them lack measures of real-world benefits such as activities of daily living.  However, where longer follow-ups and real-world benefits are measured, benefits are seen to be long lasting and quite general.  For example, in the ACTIVE study of cognitive training in normal healthy older adults, benefits to activities of daily living are seen 5 years after the training intervention ended.

While there is still much to learn, the weight of the evidence is showing that cognitive training can be highly effective when properly designed and executed.

Eating fish may reduce risk of stroke

By Gregory Kellett, a cognitive neuroscience researcher at SFSU and UCSF, and science writer for Lumos Labs.

Eating lots of fish, the ultimate brain food, was recently associated with reduced risk of stroke.

A study conducted by Jyrki Virtanen and his crew at the University of Kuopio in Finland found that people who ate more fish tended to have fewer strokes. Virtanen looked at a population of 2,313 participants over the age of 65 who had their brains scanned (via MRI) twice, with a 5-year lapse between scans. After analyzing answers the participants gave to diet-related questionnaires the researchers found that:

• Those eating fish 3 or more times a week had fewer sub-clinical infarcts or “mini-strokes” than those eating fish less than once a month.
• Consuming more fish was associated with more intact brain white matter.
• Fried fish is not so healthy, and seemed to negate the above benefits.

As seen in other research studying healthy brain food, omega-3 fatty acids, which are present in most fish oils, seem to be a key contributor to lowering the risk of stroke.

Reference: Virtanen, J. K., Siscovick, D. S., Longstreth, W. T., Kuller, L. H., & Mozaffarian, D. (2008). Fish consumption and risk of subclinical brain abnormalities on MRI in older adults. Neurology, 71(6), 439-446.

Physical Exercise and Brain Blood Flow

By Gregory Kellett, a cognitive neuroscience researcher at SFSU and science writer for Lumos Labs .

Recent findings have linked exercising regularly with increased cerebral blood flow and a greater number of blood vessels in the brain.

While it has been shown in the past that aerobic exercise might reduce cognitive decline, this study demonstrated a possible explanation: changes in the brain’s blood vessels and blood flow.

The researchers recruited 12 healthy adults, age 60 to 76. Six of the adults participated in aerobic exercise for three or more hours per week over 10 years, and six exercised less than one hour per week. All of the volunteers underwent MRI to determine cerebral blood flow and MR angiography to depict blood vessels in the brain.

Compared to the inactive group, the people who exercised regularly had more small blood vessels carrying blood through the brain, and the blood flowed in a more normal pattern.

Smoking and the Brain

By Gregory Kellett, a cognitive neuroscience researcher at SFSU and UCSF, and science writer for Lumos Labs.

A recent research review to be published in the journal Progress in Neuropsychopharmacology & Biological Psychiatry shows a link between cigarette smoking and adverse changes in the function and physiology of the brain. Summarizing the findings of dozens of experiments, the review indicates that:

• Strokes are more prevalent in smokers than non-smokers.
• Gray matter (made up of brain cells) shrinks in long-term smokers.
• Smoking is associated with less integrity in the white matter connecting brain hemispheres.
• Puffing tobacco can be bad for neurotransmitters.

There are a few factors clouding the picture however. These include the fact that alcohol consumption often accompanies cigarette smoking and has also been shown to have detrimental effects on the brain.

In addition there is the question of which comes first: brain abnormalities or smoking habits. It is possible that preexisting brain abnormalities increase the likelihood of smoking and addiction.  The author suggested more research in order to answer these questions, as well as to determine if these symptoms are reversible after quitting.

References:

Domino, E. (2008). Tobacco Smoking and MRI/MRS Brain Abnormalities Compared to Nonsmokers. Progress in Neuro-Psychopharmacology and Biological Psychiatry, In press.

Older People Learning Newer Tricks

By Gregory Kellett, a cognitive neuroscience researcher at SFSU and UCSF, and science writer for Lumos Labs.

Recent research coming out of Hamburg, Germany and published in the Journal of Neuroscience demonstrates that older brains still have the flexibility to literally grow. Researcher Janina Boyke and crew, split 50 people with an average age of 60 years into two groups. One half of the participants were trained in the fine art of juggling over the course of 3 months while the other half was not. Three MRI brain scans were taken: one before the juggling began, another after 3 months of juggling training and a yet a third after 3 months of no juggling.

The data revealed that:

• The juggling group showed significant increases in brain gray matter above the non-juggling controls. These increases took place in the hippocampus (responsible for memory formation), the nucleus accumbens (involved in reward systems) and various visual centers.

• Three months after the end of training none of the individuals from the juggling group could still juggle and the gray matter increases had declined back to baseline. (Can you say “Use it or lose it“)

The authors note the growth of the nucleus accumbens (involved in reward systems) to be of particular interest, suggesting that it may have been involved in “…turning reward information into motivated action”.

Good Cholesterol and Good Memory

By Gregory Kellett, a cognitive neuroscience researcher at SFSU and UCSF, and writer for Lumos Labs.

A recent British study published by the American Heart Association suggests that the balance of cholesterol in our blood may affect not only heart health but also memory performance. It is widely accepted that diets promoting “Good” cholesterol, otherwise known as high-density lipoprotiens (HDL), can reduce cardiovascular disease, but it now appears that high HDL may also be good for memory.

Researchers tested 3,600 British civil servants for both HDL levels and memory performance over time, first at an average age of 55 and then again at 61.

The results?

• Participants with higher HDL levels did consistently better at recalling items from a list of 20 words after 2 minutes.
• For those whose HDL levels declined between tests there were also declines in memory performance.

Reference:

Singh-Manoux, A., Gimeno, D., Kivimaki, M., Brunner, E., & Marmot, M. G. (2008). Low HDL Cholesterol Is a Risk Factor for Deficit and Decline in Memory in Midlife. The Whitehall II Study. Arterioscler Thromb Vasc Biol, 28, 1398.

Cognitive training and aging

K. Warner Schaie and Sherry L. Willis are two of the more important researchers in the area of aging and cognitive training. They oversee the Seattle Longitudinal Study, which followed adults across many years as they grew older, regularly monitoring their cognitive status. Among their most important findings:

• Through cognitive training (exercises for the brain), older people can improve their abilities.
• Those who have had a decline in their thinking abilities can get back to where they were 14 years earlier.
• Certain abilities are more likely to decline with age than others. Four abilities that typically get worse are:
  • processing speed
  • reasoning
  • memory
  • spatial orientation
• Cognitive training can impact everyday tasks. For example, reasoning training can make people better at solving problems around the household or logistics of transportation.

Reference:

Schaie, K. W., & Willis, S. L. (2005). Intellectual functioning in adulthood: Growth, maintenance, decline and modifiability. Washington, D.C.: American Society on Aging and Metlife Foundation.

Memory problems in aging men

Men more likely to have problems with memory and thinking skills

CHICAGO – When it comes to remembering things, new research shows men are more likely than women to have mild cognitive impairment, the transition stage before dementia. The research will be presented at the American Academy of Neurology 60th Anniversary Annual Meeting in Chicago, April 12–19, 2008.

“This is one of the first studies to determine the prevalence of mild cognitive impairment among men and women who have been randomly selected from a community to participate in the study,” said study author Rosebud Roberts, MD, with the Mayo Clinic in Rochester, MN, and member of the American Academy of Neurology. Mild cognitive impairment can also be described as impairment in memory or other thinking skills beyond what’s expected for a person’s age and education.

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